
Around 1,000 babies a year suffer from TTTS
(Twin to Twin Transfusion Syndrome)
Sponsored by



The Trust was founded following the tragic loss of Richard and Jack Wiseman in the summer of 1993 as a result of Twin-to-Twin Transfusion Syndrome. This little known condition accounts for the deaths of many hundreds of identical twins in single placenta pregnancies. For reasons unknown, the placental blood flow is irregular to the two babies, one receiving too much and the other not enough. This places both babies at extreme risk of a tragedy, both before and after the birth. Richard, Jack, and their mother were treated at Queen Charlotte's and Chelsea Hospital in London where research into the condition is at an advanced stage.
This research is concerned with placental bloodflow and progress is anticipated in all abnormalities of bloodflow in unborn babies, whether single or twins. Meanwhile, careful monitoring of a twin pregnancy where there is only one placenta brings other great medical benefits. Already research has led to a large saving of lives when the syndrome has been diagnosed early enough. Where twins are born having been victims of Twin-to-Twin Transfusion Syndrome, they are likely to be extremely premature.
Identical twins are not subject to a family history of multiple birth and can be carried by any mother potentially affecting anyone involved with a pregnancy. Research into blood flow disorders in the womb can benefit single babies or multiple pregnancies. The Trustees are of the opinion that the aims of the Trust will lead to the saving of many babies lives. Any help with fund raising will be most appreciated. The Trust is administered and advised, wherever possible, by kind professionals who give their time free of charge.
About the Wiseman Trust
-
Established 26 Years
-
Founded in 1993
-
Raised over £1 million in donations
-
Annual Fundraising Events
Aims
The aim is to further research the causes of the syndrome so that earlier diagnosis and treatment becomes routine with every multiple pregnancy.
Research
Funds research fellowships and equipment in the Centre for Fetal Care at Queen Charlotte’s & Chelsea Hospital and Imperial College London, and more recently at the University of Queensland, Australia.
Equipment
The Trust is also dedicated to the provision of equipment for use by Special Care Baby Units and its assistance in this area is under way.
Twins
The aim of the Wiseman Trust is to assist research which will ensure that in future Twin-to-Twin Transfusion will no longer be a threat to the lives of unborn babies.

Achievements
1
Staff Achievements
-
Published 49 original research papers and 26 review articles.
-
Awarded three PhDs (Denbow, Taylor) and two in progress
-
Two best Young Investigator Awards (Denhow, Tan) at International Fetal Medicine and Surgery Society 1999, 2003.
-
BUPA Foundation Research Award (Welsh), 2000.
-
President, International Institutes of Health TTTS Trial Committee (Fisk).
-
Gave 101 scientific presentations and 68 invited lectures in 33 countries.
2
Research Highlights
-
Showed that TTTS is not due to an excess of placental blood vessels, as previously thought, but to a paucity of compensatory vessels, resulting in one twin getting too little blood and the other too much.
-
Demonstrated that severe TTTS may cause brain injury and interfere with heart development.
-
Developed non-invasive techniques for measuring inter-twin blood flow and heart function in identical twins.
-
Devised a new ultrasound test to predict which twins will get TTTS.
-
Introduced a new staging paradigm to tailor treatment, reserving riskier treatments for severe cases.
-
Maintained the world’s largest database of identical twin pregnancies.
-
Major contributor to international trials of new treatments.
3
Clinical Service
-
Dedicated fetal surveillance and cardiology clinic for identical-twin pregnancies.
-
State-of-the-art equipment including colour Doppler, 3D/4D ultrasound and fetal MRI.
-
National and international referrals.
-
Only UK Centre offering staged therapy.
-
Only UK Centre offering full range of treatments including septostomy, endoscopic and interstitial laser and bipolar diathermy.
-
Sympathetic counselling and bereavement support.
-
Service supported by largest neonatal intensive care unit in the South-East.